Tuesday, 11 December 2018
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Dogs come in a wide variety of shapes and sizes, from Mastiffs and Great Danes to Chihuahuas and teacup Poodles, and are all part of the same Canis lupus familiaris species. But how did so many different breeds come to be, and just how closely related are they? Geneticists Heidi Parker and Elaine Ostrander, along with a team of colleagues from the National Human Genome Research Institute, set forth to figure that out; the results were published a little over a year ago.

The scientists’ interest was in the origin of the breeds, not the origins of canine domestication. Their aim was to build a family breed tree and to understand what makes some breeds more susceptible than others to certain diseases.

They worked from a sample size that included 1,346 dogs representing 161 breeds, or not quite half of all those known to exist. By comparing the differences at 150,000 spots on each dog’s genome, they built a family tree. This is still very much a work in progress, as there are at least 350 breeds of dogs.

Almost all the breeds fell into 23 groupings, called clades, and this amazing cladogram shows how the various breeds are related, not just genetically but also by common traits. For instance, hounds like Beagles, Afghans and Salukis are in one clade, and dogs bred for strength—Boxers, Bulldogs and even Boston Terriers for example—are in another.

Besides sorting breeds into clades, the study also provided estimated dates that cross-breeding occurred, and distinguished breeds geographically. Even dogs bred for a specific purpose, like herding, can show considerable diversity based on geography and time periods. As Parker noted, “This shows herding is not a recent thing. People were using dogs as workers thousands of years ago.” In contrast, Pointers and gun dogs and Spaniels share very tight genetic groupings and display little genetic variation, and their origins can be traced to Victorian England.

In another really interesting finding, the research points out how some breeds were used to create other breeds, and the extent to which DNA and the mutations it may carry can be shared across multiple clades. The Pug is great example; it was used to shrink the size of other breeds as early as the 1500s. As Parker noted, “Pug DNA is part of many other toy and small dog genomes.”

This information is important to mixed-breed dogs because knowing the breeds involved, and the clades those breeds belong to, can help in finding potential genetic health problems. One of the best examples is in diagnosing a disease such as collie eye anomaly (CEA). While CEA can appear in collie-type dogs (in the herding clade), it can also occur in Nova Scotia Duck Tolling Retrievers. This analysis shows that this Canadian sporting breed dog has either Collie or Shetland Shepherd ancestors who may have passed on the defective gene. As Robert Wayne, an evolutionary biologist at the University of California, Los Angeles, not involved with the study, observed, “Mixing has resulted in the sharing of specific genomic regions harboring mutations which cause disease in very different breeds.”

For those of us who have mixed-breed dogs, knowing the ancestry of our dogs can not only provide a treasure trove of information on behavioral tendencies and talents but also reveal potential health risks associated with specific breeds. To accurately identify a dog’s ancestry, rely on science, not guesswork. WISDOM PANEL™ is the world’s leading canine DNA test. wisdompanel.com

Cladogram of 161 Domestic Dog Breeds
Breeds that form unique clades supported by 100% of bootstraps are combined into triangles. For all other branches, a gold star indicates 90% or better, black star 70%−89%, and silver star 50%−69% bootstrap support. Breeds are listed on the perimeter of the circle. A small number of dogs do not cluster with the rest of their breed, indicated as follows: x cane paratore, + Peruvian hairless dog, # sloughi, @ country-of-origin salukis, and ˆ miniature xoloitzcuintle.
H. G.PARKER ET. AL. CELL REPORTS 19 (25 APRIL 2017) © ELSEVIER INC

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Source: https://thebark.com/content/origins-dog-family-tree

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